In addition to adversely affecting physical health, HIV/AIDS can also cause significant psychological distress. Individuals diagnosed with HIV/AIDS are often subjected to stigmatization and discrimination, receive less social support and may experience psychological symptoms such as depression and anxiety disorders. In recent years, Acceptance and Commitment Therapy (ACT) has been applied to these individuals, taking into account factors such as acceptance of the disease and stigmatization. Within the scope of this study, studies in which ACT interventions were applied in individuals diagnosed with HIV/AIDS were systematically analyzed with the PRISMA flow chart. A total of 132 studies were found in various databases, including PubMed=20, EBSCOHost=8, Science Direct=101, Google Scholar=3, in which the effects of ACT-based interventions for adults diagnosed with HIV/AIDS were examined with quantitative and/or qualitative measurement. Eight studies in which the effects of ACT-based interventions for adults diagnosed with HIV/AIDS were examined with quantitative and/or qualitative measurements were evaluated in detail. In the reviewed studies, the effects of ACT interventions on stigma, health behaviors (medication/smoking, etc.) and depression were examined. The results showed that internalized stigma, depression, smoking, needle sharing, substance use, and risky behaviors such as not participating in HIV/AIDS treatment or substance abuse treatment decreased in these individuals. After treatment, psychological resilience, psychological acceptance of HIV, and longevity increased. However, since different methods were followed in these studies, it would be useful to increase the number of randomized controlled trials for more information on the effect of the intervention.